Pesticides expenditures by farming type and incidence of Parkinson disease in farmers: A French nationwide study

Professional pesticides exposure is associated with PD risk, but it remains unclear whether specific products, which strongly depend on farming type, are specifically involved. We performed a nationwide ecological study to examine the association of expenditures for main types incidence in French farmers. used National Health Insurance database identify incident cases farmers (2010–2015). combined data agricultural census compute nine 2000 3571 cantons. The between and age/sex standardized was examined using multilevel Poisson regression, adjusted smoking, neurologists’ density, deprivation index. 10,282 were identified. Cantons highest vineyards without designation origin characterized by 16% (95% CI = 6–28%) higher (p-trend corrected multiple testing 0.006). This significant men older There no other types, including origin. increased significantly high fungicide use. result suggests that practices these may play role farms should benefit from preventive measures aiming at reducing exposure. Our highlights importance considering type studies usefulness assessment.